Description
A glycoside with diverse biological activities; inhibits NF-κB activation-induced by hydrogen peroxide, LPS, okadaic acid, ceramide, or TNF in U937 cells at 1 µg/ml; inhibits TGEV replication without inducing cytotoxicity in swine testis cells (IC50 = 147 nM); reduces OGD-induced pyramidal neuron cell death in cultured rat brain explant slices; reduces viability and inhibits migration of U87MG, A172, U251, and GBM19 glioma cells; reduces tumor size and increases survival in U78MG, GL261, and U251 glioma mouse xenograft models at 0.3 mg/kg